Welcome to the website of the

Angiogenesis Laboratory Amsterdam

Angiogenesis is a key process in cancer. It is therefore a target in the development of novel anti-cancer therapies. The Angiogenesis Laboratory Amsterdam seeks to unravel the fundamental processes and mechanisms underlying angiogenesis and vascular development. The major aim is to use new knowledge and technology for the development of new treatment modalities in the clinic.

Dutch Cancer Society event at World Cancer Day (February 4th, 2019)

Dutch TV-personality Renate Gerschtanowitz did an internship at the Angiogenesis Laboratory. She helped out with the production of a promising vaccine against the tumor vasculature. This vaccine is developed for the treatment of cancer, but is envisioned to play a role in the prevention of cancer as well. Photo: Marit van den Berg.

Please watch the movie here.


Dutch Cancer Society fundraising event 2018

On December 28th, 2018, the Dutch Cancer Society (KWF) organized a fundraising activity at the former royal palace Paleis Soestdijk. Over 20.000 lampions were enlighted to support the people that were confronted with cancer. With the raised money, KWF supports the research of the

Angiogenesis Laboratory. Dr. Else Huijbers and Prof. Arjan Griffioen were interviewed on the KWF-supported research program for the development of a cancer vaccine.

Please watch the movie here.


News items
August 2018 – Angiogenesis Laboratory publishes the capacity of the most aggressive tumor cells to get help from pericytes to form vessel-like structures. The manuscript can be found here.
June 2018 – The Dutch Cancer Society (KWF) decided to fund the Angiogenesis Laboratory’s cancer vaccination program. The KWF press release can be found here.
April 2018 – Angiogenesis publishes the consensus guidelines on the use and interpretation of angiogenesis assays. The paper is open access and can be found here.
The VUmc Master Oncology and OOA BioBusiness course will be held October 29th – November 9th. For more information please visit: http://www.ooa-graduateschool.org/biobusiness/
  • VUmc; CCA & Polikliniek
Recent research of the Angiogenesis Laboratory

PDGF and pericytes regulate vasculogenic mimicry. Thijssen et al. J.Pathol, 2018

A new technology for cancer vaccination against self-antigens. Huijbers et al, Vaccine, 2018

A cancer vaccine against VEGF. Wentink et al. PNAS 2016

Rapid identification of optimal drug combinations. Nowak-Sliwinska 2016 Nature Protoc

Key original research papers of the Angiogenesis Laboratory

PAI-1 involvment in angiogenesis. Bajou et al. Nature Med. 2014.

Rapid onset of angiogenesis after angiostatic drug discontinuation. Griffioen et al. Clin.  Cancer res. 2012

Galectin-1 is an angiogenic growth factor. Thijssen et al. Cancer Res. 2010

IL-21 is an angiogenesis inhibitor. Castermans et al. Blood 2008

Isolation of tumor endothelial cells. Van Beijnum et al. Nature Protoc 2008

Quantum dot-based imaging of angiogenesis. Mulder et al. Nano Letters 2006

Novel targets in the tumor vasculature. Van Beijnum et al. Blood 2006

Galectin-1 a key molecule in angiogenesis, Thijssen et al. PNAS 2006

Review papers of the Angiogenesis Laboratory

Role of the tumor stroma in resistance against angiostatics. Huijbers et al. Drug Resist. Update, 2016

The great escape; resistance to antiangiogenic therapy. Van Beijnum et al. Pharm Rev. 2015

Vaccination against the tumor vasculature. BBA Cancer 2015


Last updated: February 10th, 2019