button_about us.jpg (12921 bytes)button_research.jpg (13036 bytes)button_education.jpg (13628 bytes)button_newsevents.jpg (15751 bytes)button_links.jpg (10752 bytes)

 Welcome to the website of the

Angiogenesis Laboratory Amsterdam 

-o-o-o-o-o-

Angiogenesis is a key process in cancer. It is therefore a target in the development of novel anti-cancer therapies. The Angiogenesis Laboratory Amsterdam seeks to unravel the fundamental processes and mechanisms underlying angiogenesis and vascular development. The major aim is to use new knowledge and technology for the development of new treatment modalities in the clinic.



Angiogenesis Laboratory researcher

Dr. Patrycja Nowak-Sliwinska

awarded with the prestigious ERC Starting Grant.

November 2015.

 

See also Polish national newspaper:

Gazeta Wyborcza, Dec. 3rd, 2015


Recently in the news:

 

Volkskrant, March 5th, 2015. Click here for printer friendly version.

 

Dutch Cancer Society (Koningin Wilhelmina Fonds) presents

Researcher of the Week - Prof. Arjan Griffioen

'De speld uit de hooiberg berekenen'

19 October 2015

Click here for the website article (in Dutch)

 


What's new in angiogenesis?

 

► PAI-1 mediates the anti-angiogenic and pro-fibrinolytic effects of 16k-prolactin - Bajou et al, Nat.Med. 2014.

Galectin-1 mediates resistance to anti-VEGF therapy - Croci et al. Cell. 2014.

How EC metabolism regulates angiogenesis - De Bock et al. Cell 2013.

Glioblastoma stem cells generate pericytes to support vasculature and tumor growth - Cheng et al. Cell 2013.

► Role of cholesterol in angiogenesis - Fang et al Nature 2013.

► LRG1 promotes angiogenesis by modulating endothelial TGFb signalling - Wang et al. Nature 2013.


Methods, techniques and models available at the Angiogenesis Laboratory

Sorting of endothelial cells from (tumor) tissues

Gene expression or proteomic profiling of tumor angiogenesis

Microvessel density and proliferating endothelial cell assessment

Angiogenesis assessment in clinical samples

Endothelial cell migration

Assessment of mobility and motility of endothelial cells

3-D endothelial cell tube formation

The workhorse assay of the Angiogenesis Laboratory

2-D endothelial cell tube formation

Rapid screening of compounds

 

 

In vivo angiogenesis in the

chorioallantoic membrane of the chicken embryo

Rapid in vivo screening

Molecular profiling of angiogenesis

Species specific detection of >50 angiogenesis genes by real-time quantitative PCR.

 

Recent research of the Angiogenesis Laboratory

Rapid identification of optimal drug combinations

Nowak-Sliwinska et al. Nat. Protoc. 2016.

(pdf available upon inclusion in PubMed))

Vaccination strategy to angiostatic cancer therapy

Wentink et al. BBA Cancer, 2015.

The great escape; the hallmarks of resistance to antiangiogenic therapy.

Van Beijnum et al. Pharm.Rev. 2015.

 

 

In vivo activity of the ruthenium containing compound RAPTA-C

Weiss et al. Chem. Science 2014

PAI-1 mediates the anti-angiogenic and pro-fibrinolytic effects of 16k-prolactin

Bajou et al, Nat.Med. 2014.

HMGB-1 a novel tumor endothelial marker

Van Beijnum et al. Oncogene 2013

Rapid onset of angiogenesis after sunitinib discontinuation

Griffioen et al. Clin.Cancer Res. 2012

 

 



Key papers of the Angiogenesis Laboratory

 

Galectin-1 is an angiogenic growth factor.

Thijssen et al., Cancer Research, 2010.

 

IL-21 a new angiogenesis inhibitor

Castermans et al., Blood, 2008

 

Isolation of tumor endothelial cells

Van Beijnum et al. Nature Protocols, 2008

 

Quantum dot-based imaging of angiogenesis.

Mulder et al. Nano Letters, 2006.

Novel targets on tumor endothelial cells.

Van Beijnum et al. Blood, 2006.

 

Galectin-1 the receptor for anginex; a key molecule in angiogenesis

Thijssen et al, PNAS, 2006.

 

NF-kappaB in angiogenesis inhibition

Tabruyn & Griffioen, Cell Death Diff., 2007

 

 


Review papers of the Angiogenesis Laboratory

The great escape; resistance to antiangiogenic therapy.

Van Beijnum et al. Pharm.Rev. 2015.

 

The quest for optimal angiostatic combination therapy

Griffioen et al. Biochem. Soc. Trans. 2014

 

Galectins in the vasculature

Thijssen et al. BBA Cancer, 2013

 

Galectin-9 in tumor biology

Heusschen et al. BBA Cancer, 2013.

 

Photodynamic therapy

Weiss et al. BBA Cancer, 2012

 

Angiogenesis inhibition in combination with radiotherapy

Kleibeuker et al. Drug Resist Update, 2012

 

Role of platelets in angiogenesis

Sabrkhany et al., BBA Cancer, 2011

 

miRNAs in angiogenesis

Heusschen, BBA Cancer 2010

 

Signaling in vasculogenic mimicry

Paulis et al. BBA Cancer, 2010

Tumor vasculature, angiogenesis and beyond.

Hillen et al, Cancer Met. Rev., 2008

 

Angiostasis to improve immunotherapy

Griffioen, Cancer Immunol Immunother, 2008

Castermans et al, BBA Cancer, 2007

 

Anti-angiogenesis, are we tackling the problem at the right level?

Griffioen, Trends Cardiovasc. Med. 2007

 

Galectins in the tumor endothelium

Thijssen et al. Blood, 2007

 

Tumor associated macrophages.

Dirkx et al, J.Leuk.Biol. 2006

 

Tumor angiogenesis gene expression

Van Beijnum & Griffioen, Trends Mol. Med. 2006

Van Beijnum et al., BBA Cancer, 2005

 

Angiogenesis: potentials for intervention in disease

Griffioen & Molema, Pharm. Rev. 2000


News & events - The Angiogenesis Laboratory Amsterdam in the news (articles only in Dutch)

 

National newspaper, Dec. 3rd, 2015

Angiogenesis Laboratory researcher Dr. Patrycja Nowak-Sliwinska is awarded with an ERC starting grant

 

De Volkskrant, March 5th, 2015

PhD defense Andrea Weiss

 

Tracer VUMC, October, 2012

10 year lustrum of the Master Oncology programme at VUMC

 

VUMC, November 2010

AUV grants Spinoza chair to prof. dr. A.W. Griffioen

 

Medische Oncologie, March, 2007 

 

De Volkskrant, September 9th, 2006

 

 

mailb.gif (4007 bytes)

 

Last updated on

 

September 4th, 2015

Tracer VUMC, April 2009

 

Mare, Leids Universitair weekblad, March, 2008

 

Chemisch Tijdschrift, March, 2007 C2W Life Scieces,

 

Summum, December 20th, 2006

Bekkerlot 2006