Welcome to the website of the
Angiogenesis Laboratory Amsterdam
Angiogenesis is a key process in cancer. It is therefore a target in the development of novel anti-cancer therapies. The Angiogenesis Laboratory Amsterdam seeks to unravel the fundamental processes and mechanisms underlying angiogenesis and vascular development. The major aim is to use new knowledge and technology for the development of new treatment modalities in the clinic.
Dutch Cancer Society event at World Cancer Day (February 4th, 2019)
Dutch TV-personality Renate Gerschtanowitz did an internship at the Angiogenesis Laboratory. She helped out with the production of a promising vaccine against the tumor vasculature. This vaccine is developed for the treatment of cancer, but is envisioned to play a role in the prevention of cancer as well. Photo: Marit van den Berg.
Dutch Cancer Society fundraising event 2018
On December 28th, 2018, the Dutch Cancer Society (KWF) organized a fundraising activity at the former royal palace Paleis Soestdijk. Over 20.000 lampions were enlighted to support the people that were confronted with cancer. With the raised money, KWF supports the research of the
Angiogenesis Laboratory. Dr. Else Huijbers and Prof. Arjan Griffioen were interviewed on the KWF-supported research program for the development of a cancer vaccine.
Recent research of the Angiogenesis Laboratory
PDGF and pericytes regulate vasculogenic mimicry. Thijssen et al. J.Pathol, 2018
A new technology for cancer vaccination against self-antigens. Huijbers et al, Vaccine, 2018
A cancer vaccine against VEGF. Wentink et al. PNAS 2016
Rapid identification of optimal drug combinations. Nowak-Sliwinska 2016 Nature Protoc
Key original research papers of the Angiogenesis Laboratory
PAI-1 involvment in angiogenesis. Bajou et al. Nature Med. 2014.
Rapid onset of angiogenesis after angiostatic drug discontinuation. Griffioen et al. Clin. Cancer res. 2012
Galectin-1 is an angiogenic growth factor. Thijssen et al. Cancer Res. 2010
IL-21 is an angiogenesis inhibitor. Castermans et al. Blood 2008
Isolation of tumor endothelial cells. Van Beijnum et al. Nature Protoc 2008
Quantum dot-based imaging of angiogenesis. Mulder et al. Nano Letters 2006
Novel targets in the tumor vasculature. Van Beijnum et al. Blood 2006
Galectin-1 a key molecule in angiogenesis, Thijssen et al. PNAS 2006
Review papers of the Angiogenesis Laboratory
Role of the tumor stroma in resistance against angiostatics. Huijbers et al. Drug Resist. Update, 2016
The great escape; resistance to antiangiogenic therapy. Van Beijnum et al. Pharm Rev. 2015
Vaccination against the tumor vasculature. BBA Cancer 2015
Last updated: February 10th, 2019